Casey John, Cote Paul J, Toshkov Illia A, Chu Chung K, Gerin John L, Hornbuckle William E, Tennant Bud C, Korba Brent E
Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20057, USA.
Antimicrob Agents Chemother. 2005 Oct;49(10):4396-9. doi: 10.1128/AAC.49.10.4396-4399.2005.
In a small controlled study, clevudine, a potent inhibitor of hepadnaviruses, including hepatitis B virus and woodchuck hepatitis virus, suppressed hepatitis delta virus (HDV) viremia in chronically infected woodchucks. Suppression was correlated with the marked reduction of woodchuck hepatitis virus surface antigen in individual animals, consistent with the concept that repression of surface antigen expression may be a useful antiviral strategy for HDV.
在一项小型对照研究中,克来夫定是一种对包括乙型肝炎病毒和土拨鼠肝炎病毒在内的嗜肝DNA病毒有强效抑制作用的药物,它能抑制慢性感染土拨鼠体内的丁型肝炎病毒(HDV)血症。病毒血症的抑制与个体动物中土拨鼠肝炎病毒表面抗原的显著减少相关,这与表面抗原表达的抑制可能是针对HDV的一种有用的抗病毒策略这一概念相一致。