Pham David Q, Plakogiannis Roda
Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY 11201-5497, USA.
Ann Pharmacother. 2005 Nov;39(11):1870-8. doi: 10.1345/aph.1G211. Epub 2005 Sep 27.
To review clinical trials evaluating the safety and efficacy of vitamin E supplementation in cardiovascular disease and cancer prevention.
Using the MeSH search terms alpha-tocopherol, tocopherols, vitamin E, cardiovascular diseases, cancer, malignancy, and clinical trials, a literature review was conducted to identify peer-reviewed articles in MEDLINE (1966-July 2005).
Published materials including original research, and previous meta-analyses were included. Only English-language articles and trials on vitamin E alone or in combination with other vitamins or minerals were reviewed. Emphasis was placed on prospective, randomized, double-blind, placebo-controlled clinical trials.
Eight clinical studies demonstrated contradicting results regarding the benefits of vitamin E in the prevention of cardiovascular disease and cancer. There is enough evidence from large, well-designed studies to discourage the use of vitamin E in the primary prevention of cardiovascular disease. Secondary prevention requires more adequate clinical trials with selected populations to examine protective effects of vitamin E in cardiovascular disease. The findings of the studies reviewed do not provide evidence that vitamin E may reduce the risk of cancer; thus, at the present time, we do not recommend daily vitamin E intake for cancer prevention is not recommended.
Available data do not support the supplementation of vitamin E in cardiovascular disease and cancer prevention.
回顾评估补充维生素E在心血管疾病和癌症预防中安全性和有效性的临床试验。
使用医学主题词表（MeSH）检索词α-生育酚、生育酚、维生素E、心血管疾病、癌症、恶性肿瘤和临床试验，进行文献综述以识别MEDLINE（1966年 - 2005年7月）中经过同行评审的文章。
纳入发表的材料，包括原创研究和先前的荟萃分析。仅回顾英文文章以及关于单独使用维生素E或与其他维生素或矿物质联合使用的试验。重点关注前瞻性、随机、双盲、安慰剂对照的临床试验。
八项临床研究在维生素E预防心血管疾病和癌症的益处方面显示出相互矛盾的结果。来自大型、设计良好的研究有足够证据不鼓励在心血管疾病的一级预防中使用维生素E。二级预防需要对特定人群进行更充分的临床试验，以研究维生素E在心血管疾病中的保护作用。所回顾研究的结果未提供维生素E可降低癌症风险的证据；因此，目前不建议为预防癌症每日摄入维生素E。
现有数据不支持在心血管疾病和癌症预防中补充维生素E。
