Zou Sige, Sinclair Jason, Wilson Mark A, Carey James R, Liedo Pablo, Oropeza Azucena, Kalra Avash, de Cabo Rafael, Ingram Donald K, Longo Dan L, Wolkow Catherine A
National Institute on Aging, Intramural Research Program, NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA.
Mech Ageing Dev. 2007 Feb;128(2):222-6. doi: 10.1016/j.mad.2006.11.026. Epub 2006 Dec 13.
Many compounds hold promise for pharmacologic manipulation of aging. However, such claims are difficult to investigate due to time and budget constraints. Here, we took a comparative approach, using short-lived invertebrate species, to directly test the effects of two tocopherols (Vitamin E) on longevity. gamma-Tocopherol represents the most abundant tocopherol in the Western diet, while alpha-tocopherol is selectively enriched in human plasma. Both isoforms demonstrate antioxidant activity and are proposed to have anti-aging activities. We compared the effects of alpha- and gamma-tocopherol supplementation on lifespan in three invertebrate species. gamma-Tocopherol, but not alpha-tocopherol, slightly extended lifespan in nematodes, but neither significantly affected lifespan in two fly species. This study shows that a comparative approach, utilizing multiple invertebrate species, can increase the robustness of invertebrate-based pilot screens for prolongevity interventions.
许多化合物有望用于衰老的药理学调控。然而，由于时间和预算限制，此类说法难以进行研究。在此，我们采用了一种比较方法，利用寿命较短的无脊椎动物物种，直接测试两种生育酚（维生素E）对寿命的影响。γ-生育酚是西方饮食中最丰富的生育酚，而α-生育酚则选择性地富集于人体血浆中。两种异构体均具有抗氧化活性，并被认为具有抗衰老活性。我们比较了补充α-生育酚和γ-生育酚对三种无脊椎动物物种寿命的影响。γ-生育酚而非α-生育酚略微延长了线虫的寿命，但两者均未显著影响两种果蝇的寿命。这项研究表明，利用多种无脊椎动物物种的比较方法，可以提高基于无脊椎动物的长寿干预初步筛选的稳健性。
