Reimann F, Gedikoglu G, Ulŭkŭtlŭ L, Celik E
Rofo. 1979 Dec;131(6):651-6. doi: 10.1055/s-0029-1231511.
The head and skull in patients with Mediterraneen anaemia show often a marked change of the external shape due mainly to the considerable enlargement of the cranial bones. From the abnormal external appearance the suspicion may arise that the form and space of the internal cranial cavity are likewise affected and even the basic structure of the skull is altered. However, a detailed investigation of the principal angles, distances and characteristic structures of the skull made on lateral roentgenograms of these patients, a comparison of the results between cases with different intensity of the osseous changes and a confrontation with the findings in normal individuals proved that there were no major discrepancies. The essential features of the human skull were always preserved. Only in some cases with severe alterations of the cranial bones a few small deviations from the normal values could be noticed and in a little number of them signs of a slight narrowing of the cranial cavity werde to be observed. This way was probably caused by a very early, rapid and extreme enlargement of the cranial bones resulting in a kind of "premature panzer-skull."
地中海贫血患者的头部和颅骨常常显示出外部形状的显著变化，这主要是由于颅骨的显著增大。从异常的外观可能会怀疑颅内腔的形态和空间同样受到影响，甚至颅骨的基本结构也发生了改变。然而，对这些患者的头颅侧位X线片进行颅骨主要角度、距离和特征结构的详细研究，比较不同骨质改变强度病例的结果，并与正常个体的检查结果进行对照，结果证明并无重大差异。人类颅骨的基本特征始终得以保留。只有在一些颅骨严重改变的病例中，才可以注意到与正常值有一些小的偏差，其中少数病例观察到颅腔有轻微变窄的迹象。这种情况可能是由于颅骨在很早的时候就迅速极度增大，从而导致一种“早熟的装甲颅骨”。
