Szulc A, Galinska B, Tarasow E, Dzienis W, Kubas B, Konarzewska B, Walecki J, Alathiaki A S, Czernikiewicz A
Department of Psychiatry, Medical University in Bialystok, Bialystok, Poland.
Pharmacopsychiatry. 2005 Sep;38(5):214-9. doi: 10.1055/s-2005-873156.
The aim of the study was the evaluation of risperidone effect on metabolite measures in the frontal lobe, temporal lobe and thalamus in schizophrenic patients on the basis of proton magnetic resonance spectroscopy ( (1)H MRS).
A group of 14 patients with the diagnosis of schizophrenia, according to DSM-IV, were examined in the study. The patients were examined twice, once after a period of at least 7 days without neuroleptics and for the second time at least 4 weeks after stable risperidone doses.
The significant differences in the metabolite levels before and after the treatment were observed only in thalamus: an increase in myoinositol (mI) and N-acetylaspartate (NAA) levels. Positive symptoms before the treatment correlated positively with NAA level in the frontal lobes and negatively in the temporal lobes. Negative symptoms before the treatment correlated positively with Glx (a common signal for GABA, glutamine and glutamate) level in the temporal lobes.
Our results seem to confirm the influence of risperidone on the brain metabolism, specifically in the region of thalamus.
本研究旨在基于质子磁共振波谱（¹H MRS）评估利培酮对精神分裂症患者额叶、颞叶和丘脑代谢物测量值的影响。
根据《精神疾病诊断与统计手册》第四版（DSM-IV），一组14名被诊断为精神分裂症的患者参与了本研究。患者接受了两次检查，一次是在至少7天未使用抗精神病药物后，另一次是在利培酮剂量稳定至少4周后。
仅在丘脑中观察到治疗前后代谢物水平的显著差异：肌醇（mI）和N-乙酰天门冬氨酸（NAA）水平升高。治疗前的阳性症状与额叶中的NAA水平呈正相关，与颞叶中的NAA水平呈负相关。治疗前的阴性症状与颞叶中的Glx（γ-氨基丁酸、谷氨酰胺和谷氨酸的共同信号）水平呈正相关。
我们的结果似乎证实了利培酮对脑代谢的影响，特别是在丘脑区域。
