Bonakdar Robert Alan, Guarneri Erminia
Scripps Center for Integrative Medicine, La Jolla, California 92037, USA.
Am Fam Physician. 2005 Sep 15;72(6):1065-70.
Coenzyme Q10 is a vitamin-like substance used in the treatment of a variety of disorders primarily related to suboptimal cellular energy metabolism and oxidative injury. Studies supporting the efficacy of coenzyme Q10 appear most promising for neurodegenerative disorders such as Parkinson's disease and certain encephalomyopathies for which coenzyme Q10 has gained orphan drug status. Results in other areas of research, induding treatment of congestive heart failure and diabetes, appear to be contradictory or need further clarification before proceeding with recommendations. Coenzyme Q10 appears to be a safe supplement with minimal side effects and low drug interaction potential.
辅酶Q10是一种类似维生素的物质,用于治疗多种主要与细胞能量代谢欠佳和氧化损伤相关的疾病。支持辅酶Q10疗效的研究对于神经退行性疾病(如帕金森病和某些脑肌病)似乎最具前景,辅酶Q10已在这些疾病上获得孤儿药地位。在其他研究领域(包括充血性心力衰竭和糖尿病的治疗)的结果似乎相互矛盾,或在提出建议之前需要进一步阐明。辅酶Q10似乎是一种安全的补充剂,副作用极小,药物相互作用的可能性也很低。