Matsumura T, Kumakiri M, Ohkawara A, Himeno H, Numata T, Adachi R
Department of Dermatology, Hokkaido University School of Medicine, Sapporo, Japan.
J Dermatol. 1992 Feb;19(2):87-93. doi: 10.1111/j.1346-8138.1992.tb03186.x.
Electron microscopic and X-ray microanalytic studies were performed on four cases of argyria; one generalized and three localized. Deposition of electron dense granules was predominantly found on elastic fibers and around basal laminas of secretory portions of eccrine glands, although the amount of deposition was much less in the case of generalized argyria. In all four cases, X-ray microanalysis revealed that the depositions consisted mainly of silver, selenium, and sulfur. The importance of selenium in the detoxification of heavy metals was discussed.
对4例银沉着病患者进行了电子显微镜和X射线微量分析研究；1例全身性和3例局限性。电子致密颗粒主要沉积在弹性纤维和小汗腺分泌部基底膜周围，尽管全身性银沉着病患者的沉积量要少得多。在所有4例患者中，X射线微量分析显示沉积物主要由银、硒和硫组成。讨论了硒在重金属解毒中的重要性。
