Bleehen S S, Gould D J, Harrington C I, Durrant T E, Slater D N, Underwood J C
Br J Dermatol. 1981 Jan;104(1):19-26. doi: 10.1111/j.1365-2133.1981.tb01706.x.
Microscopic studies have been performed on skin biopsies from five patients with occupational argyria. Small brown-black granules were present in the dermis on light microscopy and were intensely refractile with dark-field illumination. Electron microscopy showed that the granules were electron-dense, round or oval in shape and varied in size from 30 nm to 100 nm. They were most numerous in relation to the basal lamina of the eccrine sweat glands, but were also present in relation to the basal lamina of the epidermis and dermal elastic fibres. X-ray microanalysis confirmed that many of the granules contained silver and sulphur. However, selenium, mercury, titanium and iron were also identified and it is probable that these elements were deposited in the skin also as a result of occupational exposure.
对五名职业性银质沉着病患者的皮肤活检标本进行了显微镜检查。光学显微镜下，真皮中可见小的棕黑色颗粒，暗视野照明下具有强烈的折光性。电子显微镜显示，这些颗粒电子密度高，呈圆形或椭圆形，大小在30纳米至100纳米之间。它们在小汗腺基底膜周围最为密集，但在表皮基底膜和真皮弹性纤维周围也有存在。X射线微分析证实，许多颗粒含有银和硫。然而，还鉴定出了硒、汞、钛和铁，这些元素很可能也是职业暴露导致在皮肤中沉积的。
