Reymond J L, Stoebner P, Amblard P
Ann Dermatol Venereol. 1980 Apr;107(4):251-5.
This study was done in order to follow the fate of silver in the dermis of chronic argyria. Silver was easily recognizable in the tissue as irregular aggregates of elementary granules round or ovoid in shape, ranging from 30 to 40 mm in size. The microanalysis X showed that the metal was bound with sulfur. In the cases of recent intoxication, the main location of silver was intracellular: the granules were found in the lysosomes as elementary particle or as dense heterogen bodies. In the cases where intoxication had been stopped a long time ago, silver was found either on fibrillar component of the connective tissue or in the basal material of sweat glands. The results show that silver is at first phagocytized by macrophages but this cell is unable to perform complete degradation of the silver salt or metal. Then silver is found on connective fibers where it remains on sulfated glycoproteins.
本研究旨在追踪慢性银质沉着病真皮中银的去向。在组织中，银很容易被识别为形状为圆形或椭圆形的不规则基本颗粒聚集体，大小在30至40微米之间。微量分析X显示该金属与硫结合。在近期中毒的病例中，银的主要位置在细胞内：颗粒以基本粒子或致密异质体的形式存在于溶酶体中。在中毒已停止很长时间的病例中，银要么存在于结缔组织的纤维成分上，要么存在于汗腺的基底物质中。结果表明，银首先被巨噬细胞吞噬，但这种细胞无法完全降解银盐或金属。然后银出现在结缔组织纤维上，并留在硫酸化糖蛋白上。
