Niederhafner Petr, Sebestík Jaroslav, Jezek Jan
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.
J Pept Sci. 2005 Dec;11(12):757-88. doi: 10.1002/psc.721.
Dendrimers are branched structures and represent a fast growing field covering many areas of chemistry. Various types of dendrimers differing in composition and structure are mentioned, together with their practical use spanning from catalysis, transport vehicles to synthetic vaccines. The main stress is given to peptide dendrimers, namely, multiple antigenic peptides (MAPs). Their synthesis, physicochemical properties, biological activities, etc. have been described with many examples. MAPs can be used as diagnostics, mimetics, for complexation of different cations, as vaccines against parasites, bacteria, viruses, etc.
树枝状聚合物是分支结构，代表了一个快速发展的领域，涵盖了化学的许多领域。文中提到了各种组成和结构不同的树枝状聚合物，以及它们从催化、运输载体到合成疫苗等方面的实际应用。主要强调了肽树枝状聚合物，即多抗原肽（MAPs）。文中通过许多实例描述了它们的合成、物理化学性质、生物活性等。MAPs可用作诊断试剂、模拟物、用于络合不同阳离子、作为抗寄生虫、细菌、病毒等的疫苗。
