Departament de Química, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain.
Org Lett. 2010 Jul 16;12(14):3148-51. doi: 10.1021/ol1010664.
Five new highly functionalized cyclobutane containing C(3)-symmetric peptide dendrimers have been synthesized through a convergent approach from 1,3,5-trisubstituted benzene and chiral gamma,epsilon-amino diacid derivatives as well as a gamma-tetrapeptide. The first example of the synthesis of N-centered amides by using 1,3,5-triaminobenzene and a carboxylic acid is reported.
已经通过从 1,3,5-三取代苯和手性γ,ε-氨基二酸衍生物以及γ-四肽出发的收敛方法合成了五个新的高度官能化的含环丁烷的 C(3)对称肽树状大分子。本文首次报道了使用 1,3,5-三氨基苯和羧酸合成 N-中心酰胺。
