Joshi Vinay Ganeshrao, Dighe Vikas D, Thakuria Dimpal, Malik Yashpal Singh, Kumar Satish
Central Instrumentation Facility (Bio-engineering), Division Veterinary Biotechnology, Indian Veterinary Research Institute, Izatnagar, 243 122 UP India.
Central Instrumentation Facility, Standardization Division, Indian Veterinary Research Institute, Izatnagar, 243 122 UP India.
Indian J Virol. 2013 Dec;24(3):312-20. doi: 10.1007/s13337-013-0162-z. Epub 2013 Sep 6.
The peptide dendrimer provides novel strategies for various biological applications. Assembling of peptide in macromolecular structure is expected to give rational models as drugs, their delivery and diagnostic reagents. Improved understanding of virus structure and their molecular interactions with ligands have paved the way for treatment and control of emerging and re-emerging viral diseases. This review presents a brief account of a synthetic peptide dendrimer used for diagnostic, therapeutic and prophylactic applications. The designs comprise of multiple antigenic peptides which are being used as alternate synthetic antigens for different viruses.
肽树枝状大分子为各种生物学应用提供了新策略。将肽组装成大分子结构有望得到作为药物、其递送载体和诊断试剂的合理模型。对病毒结构及其与配体的分子相互作用的深入了解为治疗和控制新出现和再次出现的病毒性疾病铺平了道路。本综述简要介绍了用于诊断、治疗和预防应用的合成肽树枝状大分子。这些设计包含多种抗原肽，它们正被用作不同病毒的替代合成抗原。
