Sankararaman Sumithra, Marko John F
Department of Physics, University of Illinois at Chicago, 60607, USA.
Phys Rev Lett. 2005 Aug 12;95(7):078104. doi: 10.1103/PhysRevLett.95.078104. Epub 2005 Aug 11.
We solve a model for the equilibrium folding of DNA via the formation of randomly placed (nonspecific) loops. We find that the loop rearrangement entropy drives a significant reduction in loop size as more loops form. The reduction of the most probable loop size occurs over a wide range of forces and is enhanced by interloop cooperativity, indicating that it should be observable in single DNA experiments.
我们通过随机放置（非特异性）环的形成来求解DNA平衡折叠的模型。我们发现，随着更多环的形成，环重排熵驱动环尺寸显著减小。最可能的环尺寸的减小发生在很宽的力范围内，并且通过环间协同作用而增强，这表明它应该在单个DNA实验中是可观察到的。
