Yilmaz Mustafa, Ozütemiz Omer, Karasu Zeki, Ersöz Galip, Günsar Fulya, Batur Yücel, Aydin Ahmet, Tekesin Oktay, Yönetci Nadir, Ilter Tankut
Department of Gastroenterology, School of Medicine, Pamukkale University, Denizli, Turkey.
Hepatogastroenterology. 2005 Sep-Oct;52(65):1622-5.
BACKGROUND/AIMS: Dieulafoy's lesion is a rare cause of upper gastrointestinal bleeding and is potentially life threatening. The aim of this study is to determine the clinical features of these lesions and the efficacy of the endoscopic injection sclerotherapy in patients with Dieulafoy's lesion.
Between January 1994 and December 2001, twenty-eight patients with upper gastrointestinal bleeding due to Dieulafoy's lesion were treated by endoscopic injection sclerotherapy. Efficacy of endoscopic therapy and clinical findings of these cases were analyzed.
The study group consisted of 22 male (78.5%) and 6 female (21.5%) patients with a mean age of 57 years (range 22-82 years). Significant comorbidity was present in 22 (78.5%) patients. Hemoglobin values of the patients ranged from 5.4-10.3 g/dL at hospitalization. The median transfusion requirement was 5 (range 0-12) units. Dieulafoy's lesion was observed in the proximal half of stomach in 25 cases (89.3%), in the antrum in 2 cases (7.1%) and in the angulus in 1 case (3.5%). Endoscopic injection sclerotherapy was successful in stopping the bleeding in 26 out of 28 patients (92.8%).
Dieulafoy's lesions mostly affect the proximal stomach and cause serious upper gastrointestinal bleeding. Endoscopic injection sclerotherapy is an effective and a safe therapeutic method for Dieulafoy's lesion.
背景/目的：Dieulafoy病是上消化道出血的罕见病因，有潜在生命危险。本研究旨在确定这些病变的临床特征以及内镜注射硬化疗法对Dieulafoy病患者的疗效。
1994年1月至2001年12月期间，28例因Dieulafoy病导致上消化道出血的患者接受了内镜注射硬化疗法治疗。分析了内镜治疗的疗效及这些病例的临床发现。
研究组包括22例男性（78.5%）和6例女性（21.5%）患者，平均年龄57岁（范围22 - 82岁）。22例（78.5%）患者存在显著的合并症。患者住院时血红蛋白值在5.4 - 10.3 g/dL之间。输血需求量中位数为5（范围0 - 12）单位。25例（89.3%）Dieulafoy病病变位于胃近端半部，2例（7.1%）位于胃窦，1例（3.5%）位于胃角。28例患者中有26例（92.8%）通过内镜注射硬化疗法成功止血。
Dieulafoy病主要影响胃近端，导致严重的上消化道出血。内镜注射硬化疗法是治疗Dieulafoy病的一种有效且安全的治疗方法。
