Rektor I, Svejdová M, Silva-Barrat C, Menini C
Clinic of Neurology, Masaryk University, Brno, Czechoslovakia.
Mov Disord. 1992;7(3):224-7. doi: 10.1002/mds.870070306.
The effect of two drugs upon multifocal myoclonic jerks was evaluated. The drugs influence the central cholinergic system in opposite ways. Eight patients with progressive and nonprogressive myoclonic epilepsy were tested. The single blind test was used. The number of myoclonic jerks after intravenous physostigmine (mean dose 0.02 mg/kg) and that after atropine (0.04 mg/kg) was compared to number of myoclonic jerks in the drug-free periods and with placebo. Placebo was without an effect. Physostigmine slightly increased the number of jerks. Atropine decreased the number significantly. In most patients the results were not striking. It is suggested that the cholinergic system may participate in the physiopathology of the studied myoclonus in a rather indirect, perhaps modulating way.
评估了两种药物对多灶性肌阵挛性抽搐的影响。这两种药物以相反的方式影响中枢胆碱能系统。对8例进行性和非进行性肌阵挛性癫痫患者进行了测试。采用单盲试验。将静脉注射毒扁豆碱（平均剂量0.02mg/kg）和阿托品（0.04mg/kg）后肌阵挛性抽搐的次数与无药期及安慰剂情况下肌阵挛性抽搐的次数进行比较。安慰剂无效。毒扁豆碱使抽搐次数略有增加。阿托品则显著减少了抽搐次数。在大多数患者中，结果并不显著。提示胆碱能系统可能以一种相当间接、或许是调节性的方式参与了所研究肌阵挛的病理生理过程。
