Xu Li, Wei Cui-E, Zhao Ming-Bo, Wang Jian-Nong, Tu Peng-Fei, Liu Jian-Xun
Research Center of Xiyuan Hospital, China Academy Traditional Chinese Medicine, Beijing 100091, China.
Zhongguo Zhong Yao Za Zhi. 2005 Aug;30(15):1184-8.
To investigate pharmacological effects of the total flavonoid in Hypericum perforatum on depression.
Experimental depression was induced by subcutaneous injection of reserpine in mice. The concentration of monoamine transmitters including 5-HT and NE, the activity of monoamine oxidase (MAO) in brain and reserpine-induced symptoms of depression, such as ptosis, attenuation of autonomous activity, behavioral despair, acquired helplessness and sleep, were measured respectively to evaluate the effects of the total flavonoid in H. perforatum on the depression.
The total flavonoid in H. perforatum significantly decreased the activity of MAO, inhibited the ptosis and the attenuation of autonomous behavior induced by reserpine respectively. The levels of 5-HT and NE were also attenuated by the total flavonoid in H. perforatum remarkably. In addition, the total flavonoid in H. perforatum was shown to inhibit behavioral despair and acquired helplessness and to prolong the sleep time in the mice. Following the treatment with the total flavonoid in H. perforatum, 5-THP, at the dosage without any side-effects, caused the tremble in the mice.
The results indicate that total flavonoid in H. perforatum can significantly inhibit the depression.
研究贯叶连翘总黄酮对抑郁症的药理作用。
通过皮下注射利血平诱导小鼠产生实验性抑郁。分别测定包括5-羟色胺（5-HT）和去甲肾上腺素（NE）在内的单胺递质浓度、脑中单胺氧化酶（MAO）的活性以及利血平诱导的抑郁症状，如眼睑下垂、自主活动减弱、行为绝望、习得性无助和睡眠情况，以评估贯叶连翘总黄酮对抑郁症的影响。
贯叶连翘总黄酮显著降低了MAO的活性，分别抑制了利血平诱导的眼睑下垂和自主行为减弱。贯叶连翘总黄酮还显著降低了5-HT和NE的水平。此外，贯叶连翘总黄酮显示出能抑制小鼠的行为绝望和习得性无助，并延长睡眠时间。在用贯叶连翘总黄酮5-THP治疗后，在无任何副作用的剂量下，小鼠出现了颤抖。
结果表明贯叶连翘总黄酮能显著抑制抑郁症。
