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金丝桃苷对氧化应激诱导的人类疾病的潜在影响：综述

Potential Implications of Hyperoside on Oxidative Stress-Induced Human Diseases: A Comprehensive Review.

作者信息

Wang Kaiyang, Zhang Huhai, Yuan Lie, Li Xiaoli, Cai Yongqing

机构信息

Department of Pharmacy, Daping Hospital, Army Medical University, Chongqing, People's Republic of China.

Department of Nephrology, Southwest Hospital, Army Medical University, Chongqing, People's Republic of China.

出版信息

J Inflamm Res. 2023 Oct 13;16:4503-4526. doi: 10.2147/JIR.S418222. eCollection 2023.

DOI:10.2147/JIR.S418222
PMID:37854313
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10581022/
Abstract

Hyperoside is a flavonol glycoside mainly found in plants of the genera and , and also detected in many plant species such as , , , , and . This compound exhibits a multitude of biological functions including anti-inflammatory, antidepressant, antioxidative, vascular protective effects and neuroprotective effects, etc. This review summarizes the quantification, original plant, chemical structure and property, structure-activity relationship, pharmacologic effect, pharmacokinetics, toxicity and clinical application of hyperoside, which will be significant for the exploitation for new drug and full utilization of this compound.

摘要

金丝桃苷是一种黄酮醇苷，主要存在于[此处原文未给出具体属名]属植物中，在许多植物物种如[此处原文未给出具体植物名]、[此处原文未给出具体植物名]、[此处原文未给出具体植物名]、[此处原文未给出具体植物名]、[此处原文未给出具体植物名]和[此处原文未给出具体植物名]中也有检测到。该化合物具有多种生物学功能，包括抗炎、抗抑郁、抗氧化、血管保护作用和神经保护作用等。本综述总结了金丝桃苷的定量分析、原始植物、化学结构与性质、构效关系、药理作用、药代动力学、毒性及临床应用，这对于该化合物的新药开发和充分利用具有重要意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbd0/10581022/450abdfde014/JIR-16-4503-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbd0/10581022/84f4538b5c4f/JIR-16-4503-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbd0/10581022/6ee3d3b06e08/JIR-16-4503-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbd0/10581022/450548b836ae/JIR-16-4503-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbd0/10581022/450abdfde014/JIR-16-4503-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbd0/10581022/84f4538b5c4f/JIR-16-4503-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbd0/10581022/6ee3d3b06e08/JIR-16-4503-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbd0/10581022/450548b836ae/JIR-16-4503-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbd0/10581022/450abdfde014/JIR-16-4503-g0004.jpg

相似文献

[1]
Potential Implications of Hyperoside on Oxidative Stress-Induced Human Diseases: A Comprehensive Review.

J Inflamm Res. 2023-10-13

[2]
Application of microdialysis for elucidating the existing form of hyperoside in rat brain: comparison between intragastric and intraperitoneal administration.

J Ethnopharmacol. 2012-10-12

[3]
Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity.

Molecules. 2022-5-7

[4]
Hyperoside: A review on its sources, biological activities, and molecular mechanisms.

Phytother Res. 2022-7

[5]
Development and application of a rapid HPLC method for simultaneous determination of hyperoside, isoquercitrin and eleutheroside E in L. and .

BMC Chem. 2020-5-2

[6]
Antidepressant-like effect of hyperoside isolated from Apocynum venetum leaves: possible cellular mechanisms.

Phytomedicine. 2011-7-28

[7]
Hyperoside exerts anti-inflammatory and anti-arthritic effects in LPS-stimulated human fibroblast-like synoviocytes in vitro and in mice with collagen-induced arthritis.

Acta Pharmacol Sin. 2016-5

[8]
Hyperoside Protects HK-2 Cells Against High Glucose-Induced Apoptosis and Inflammation the miR-499a-5p/NRIP1 Pathway.

Pathol Oncol Res. 2021

[9]
Hyperoside and rutin of induce mitochondrial apoptosis through a caspase-dependent mechanism in HT-29 human colon cancer cells.

Oncol Lett. 2016-4

[10]
Anti-platelet aggregation activities of different fractions in leaves of Apocynum venetum L.

J Ethnopharmacol. 2015-3-31

引用本文的文献

[1]
Phenolic Compounds in Nectar of Jacq. and L.

Plants (Basel). 2025-7-6

[2]
Herbal Immunostimulants and Their Phytochemicals: Exploring , , and .

Plants (Basel). 2025-3-13

[3]
The Diversity of Morphological Traits and Seed Metabolomic Composition in Buckwheat Genetic Resources.

Plants (Basel). 2025-3-13

[4]
Optimization of Microwave-Assisted Extraction of Polyphenols from L.

Antioxidants (Basel). 2025-3-18

[5]
Screening and validation of optimal real-time PCR reference genes for Abelmoschus Manihot.

Sci Rep. 2025-4-1

[6]
Exploring the Utility of Extracts as a Source of Natural Bioactive Compounds for Functional Applications.

Food Sci Nutr. 2025-3-28

[7]
Targeting the NLRP3 by Natural Compounds: Therapeutic Strategies to Mitigate Doxorubicin-Induced Cardiotoxicity.

Cell Biochem Biophys. 2025-3-18

[8]
The multiple biological activities of hyperoside: from molecular mechanisms to therapeutic perspectives in neoplastic and non-neoplastic diseases.

Front Pharmacol. 2025-3-3

[9]
Phytochemical Composition of (L.) Lam and Its Impact on the Metabolic Syndrome: A Review.

Adv Pharmacol Pharm Sci. 2025-2-17

[10]
Versatility of Caenorhabditis elegans as a Model Organism for Evaluating Foodborne Neurotoxins and Food Bioactive Compounds in Nutritional Neuroscience.

Mol Neurobiol. 2025-6

本文引用的文献

[1]
Assessment of hypolipidemic and anti-inflammatory properties of walnut (Juglans regia) seed coat extract and modulates some metabolic enzymes activity in triton WR-1339-induced hyperlipidemia in rat kidney, liver, and heart.

J Mol Recognit. 2023-3

[2]
Isolation of Some Phenolic Compounds from Plantago subulata L. and Determination of Their Antidiabetic, Anticholinesterase, Antiepileptic and Antioxidant Activity.

Chem Biodivers. 2022-8

[3]
Some indazoles as alternative inhibitors for potato polyphenol oxidase.

Biotechnol Appl Biochem. 2022-10

[4]
Study on Active Components of Promoting Neural Stem Cells Proliferation: Bioassay-Guided Fractionation.

Molecules. 2021-11-2

[5]
Hyperoside suppresses BMP-7-dependent PI3K/AKT pathway in human hepatocellular carcinoma cells.

Ann Transl Med. 2021-8

[6]
Molecular docking and inhibition studies of vulpinic, carnosic and usnic acids on polyol pathway enzymes.

J Biomol Struct Dyn. 2022

[7]
Hyperoside Protects HK-2 Cells Against High Glucose-Induced Apoptosis and Inflammation the miR-499a-5p/NRIP1 Pathway.

Pathol Oncol Res. 2021

[8]
Hyperoside Attenuate Inflammation in HT22 Cells via Upregulating SIRT1 to Activities Wnt/-Catenin and Sonic Hedgehog Pathways.

Neural Plast. 2021

[9]
Bovine β-Lactoglobulin Covalent Modification by Flavonoids: Effect on the Allergenicity and Human Intestinal Microbiota.

J Agric Food Chem. 2021-6-23

[10]
The role and mechanism of hyperoside against myocardial infarction in mice by regulating autophagy via NLRP1 inflammation pathway.

J Ethnopharmacol. 2021-8-10

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