[三种金丝桃属药用植物乙醇提取物对小鼠的抗抑郁作用]
[Antidepressant effect of ethanol extracts from three species of sect. Hypericum medicinal plants in mice].
作者信息
Wan Deguan, Pei Jin, Zhou Mingmei, Wang Guangzhi
机构信息
Chengdu University of Traditional Chinese Medicine, 610075.
出版信息
Zhong Yao Cai. 2003 Mar;26(3):187-9.
OBJECTIVE
To explore the antidepressant actions of ethanol extracts from three species of sect. Hypericum medicinal plants.
METHODS
The forced swimming test and mouse tail suspensions in mice were used.
RESULT
Ethanol extracts of sect. Hypericum medicinal plants significantly shortened motionless time of mice forced swimming and despair time of mouse tail suspension in the two behavior despair animal models of depression. The effect of H. faberi was weaker than that of H. perforatum.
CONCLUSION
These findings demonstrated that the extracts from three species of sect. Hypericum medicinal plants possessed obvious antidepressant activity.
目的
探讨金丝桃属三种药用植物乙醇提取物的抗抑郁作用。
方法
采用小鼠强迫游泳试验和小鼠尾悬挂试验。
结果
金丝桃属药用植物乙醇提取物在两种行为绝望型抑郁动物模型中，均能显著缩短小鼠强迫游泳不动时间和小鼠尾悬挂绝望时间。贯叶连翘的作用强于元宝草。
结论
这些结果表明金丝桃属三种药用植物提取物具有明显的抗抑郁活性。
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