Lee Myung Ah, Park Gyeong-sin, Lee Hee-Jung, Jung Ji-Han, Kang Jin-Hyoung, Hong Young Seon, Lee Kyung Shik, Kim Dong-gu, Kim Seung-Nam
Division of Oncology, Department of Internal Medicine, Catholic University of Medical College, Seoul, Korea.
BMC Cancer. 2005 Oct 4;5:127. doi: 10.1186/1471-2407-5-127.
Survivin, an inhibitor of apoptosis is expressed in several human cancers. Its expression is known to be associated with poor clinical outcome, but not widely studied in pancreatic cancer. We performed this study to determine the survivin expression in pancreatic cancer and its clinical significance as a prognostic factor.
We performed immunohistochemical staining for survivin, p53, and Bax in formalin-fixed, paraffin-embedded block from forty-nine pancreatic tissues. To determine the association with clinical course, we reviewed the patients' clinical record.
Of the 49 cases of pancreatic cancer, 46 cases (93.9%) were positive for survivin expression. There was no significant association between survivin expression and p53 or bax. For clinicopathological parameters, perineural invasion was more common in survivin positive and venous invasion was more common in survivin negative (p = 0.041 and 0.040, respectively). Responsiveness to chemotherapy appeared to be slightly better in patients with low survivin expression.
Survivin expression may be associated with venous or perineural invasion, indicating metastatic route, and seems to have a potential as a predictive marker for chemotherapy. Further study of large scale is required to determine the clinical significance of survivin expression in pancreatic cancer.
生存素作为一种凋亡抑制因子，在多种人类癌症中均有表达。已知其表达与临床预后不良相关，但在胰腺癌中的研究尚不广泛。我们开展本研究以确定生存素在胰腺癌中的表达情况及其作为预后因素的临床意义。
我们对49份胰腺组织的福尔马林固定石蜡包埋块进行了生存素、p53和Bax的免疫组化染色。为确定其与临床病程的关联，我们查阅了患者的临床记录。
在49例胰腺癌病例中，46例（93.9%）生存素表达呈阳性。生存素表达与p53或Bax之间无显著关联。就临床病理参数而言，神经周围侵犯在生存素阳性病例中更为常见，而血管侵犯在生存素阴性病例中更为常见（p值分别为0.041和0.040）。生存素低表达患者对化疗的反应似乎略好。
生存素表达可能与血管或神经周围侵犯相关，提示转移途径，并且似乎具有作为化疗预测标志物的潜力。需要进一步开展大规模研究以确定生存素表达在胰腺癌中的临床意义。
