抗凋亡基因Survivin的表达预示着III期胃腺癌的预后不良。
Expression of the antiapoptosis gene Survivin predicts poor prognosis of stage III gastric adenocarcinoma.
作者信息
Song Kyo Young, Jung Chan Kwon, Park Won Sang, Park Cho Hyun
机构信息
Department of Surgery, Division of Gastrointestinal Surgery, The Catholic University of Korea, College of Medicine, Kangnam St Mary's Hospital, Seocho-Gu, Seoul, Republic of Korea.
出版信息
Jpn J Clin Oncol. 2009 May;39(5):290-6. doi: 10.1093/jjco/hyp020. Epub 2009 Mar 31.
OBJECTIVE
This study was designed to determine the level of survivin expression and its clinical significance as a prognostic factor in Stage III gastric adenocarcinoma.
METHODS
We performed immunohistochemical staining for survivin, p53 and Bax in formalin-fixed, paraffin-embedded blocks from 157 surgically resected Stage III gastric cancer tissues. To determine the association with clinical course, we reviewed the patients' clinical records.
RESULTS
Of the 157 gastric cancer tissues, 63 (40.1%) cases showed positive expression for survivin protein. There was no significant association between survivin expression and p53 or Bax. For clinicopathologic parameters, large tumor size was closely related to survivin expression (P < 0.05). The 5-year survival rate of patients with positive survivin expression was significantly lower compared with that for survivin-negative cancer patients (P < 0.05). Survivin and p53 were independent prognostic factors in Stage III gastric cancer.
CONCLUSIONS
Survivin protein is an important predictive and prognostic parameter of poor outcome in gastric carcinoma.
目的
本研究旨在确定生存素表达水平及其作为Ⅲ期胃腺癌预后因素的临床意义。
方法
我们对157例手术切除的Ⅲ期胃癌组织的福尔马林固定、石蜡包埋块进行了生存素、p53和Bax的免疫组化染色。为了确定与临床病程的关联，我们查阅了患者的临床记录。
结果
在157例胃癌组织中，63例（40.1%）生存素蛋白表达呈阳性。生存素表达与p53或Bax之间无显著关联。对于临床病理参数，肿瘤体积大与生存素表达密切相关（P<0.05）。生存素表达阳性患者的5年生存率明显低于生存素阴性癌症患者（P<0.05）。生存素和p53是Ⅲ期胃癌的独立预后因素。
结论
生存素蛋白是胃癌预后不良的重要预测和预后参数。
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