Zhao Lan-jiang, Zhao Dong, Liu Jing, Wang Wei, Wu Gui-xian, Qin Lan-ping, Liu Jun, Liu Sa, Wang Wen-hua, Zeng Zhe-chun
Department of Epidemiology, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Capital University Affiliationg Beijing Anzhen Hospital, Beijing 100029, China.
Zhonghua Nei Ke Za Zhi. 2005 Sep;44(9):664-7.
To Study the association between the level of serum uric acid and triglyceride in a Chinese population.
In 1999, a cross-sectional study was carried out in a natural population of Beijing, using stratified-random sampling method. Serum uric acid and triglyceride were measured in 1239 subjects.
The prevalence of hypertriglyceridemia significantly increased with increased level of serum uric acid among both the men and women. After adjusting BMI, HOMA index and alcohol consumption level with stratified methods, the incidence of hypertriglyceridemia increased with increasing level of basal serum uric acid in different levels of BMI, HOMA index and alcohol consumption. After adjusting gender, age, BMI, HOMA index, total cholesterol, smoking and alcohol consumption, the results of multivariate logistic regression analyses indicated that the odds ratio for hypertriglyceridemia as compared with the lowest quartile of serum uric acid was 1.26 (P = 0.28) for the second quartile, 1.88 (P = 0.002) for the third quartile, and 3.36 (P < 0.001) for the highest quartile.
Serum uric acid level was strongly associated with triglyceride independent of age, genders, smoking, alcohol consumption, obesity and insulin resistance.
研究中国人群血清尿酸水平与甘油三酯之间的关联。
1999年,采用分层随机抽样方法,对北京的一个自然人群进行了横断面研究。对1239名受试者测量了血清尿酸和甘油三酯。
男性和女性中,高甘油三酯血症的患病率均随血清尿酸水平的升高而显著增加。采用分层方法调整BMI、HOMA指数和饮酒水平后,在不同BMI、HOMA指数和饮酒水平下,高甘油三酯血症的发病率随基础血清尿酸水平的升高而增加。调整性别、年龄、BMI、HOMA指数、总胆固醇、吸烟和饮酒后,多因素logistic回归分析结果显示,与血清尿酸最低四分位数相比,高甘油三酯血症的比值比在第二四分位数为1.26(P = 0.28),第三四分位数为1.88(P = 0.002),最高四分位数为3.36(P < 0.001)。
血清尿酸水平与甘油三酯密切相关,不受年龄、性别、吸烟、饮酒、肥胖和胰岛素抵抗的影响。