The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Shandong, 250014, China.
Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Shandong, 250014, China.
Lipids Health Dis. 2024 Jun 24;23(1):195. doi: 10.1186/s12944-024-02182-1.
Uric acid (UA), a liver-derived metabolite, is intimately tied to metabolic disorders. Although ample research underscores its connection with hypertriglyceridemia (HTG), studies focusing on adolescents remain limited. To fill the gaps in epidemiology,this study focused on analyzing the relationship between the levels of uric acid and HTG in a demographic sample comprising adolescents from the United States.
In this study, a total of 4,435 participants through the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2020. The exposure variable was serum uric acid (SUA), the effect variable was HTG, and the covariates included demographic, questionnaire, physical examination and laboratory indicators. We utilized weighted logistic regression and meticulous subgroup evaluations to discern the intrinsic link between SUA and HTG. Stratified analyses augmented the validation of this association, while smooth curve fitting probed for potential nonlinear correlations.
The study included 4,435 participants. Male adolescents exhibit elevated SUA levels. After adjusting for all variables, the weighted multiple logistic regression model revealed that SUA was positively correlated with HTG risk (OR = 1.006, 95% CI: 1.005-1.007). This relationship was consistent across the three tertiles group of SUA (T1: OR = 1.006 [95% CI: 1.005-1.007]; T2: OR = 1.006 [95% CI: 1.005-1.007]; T3: OR = 1.004 [95% CI: 1.003-1.006]; P for trend < 0.001). Stratified analyses confirmed that the positive correlation between SUA and HTG risk was significant, irrespective of sex, age or race.
In American children and adolescents aged 12 to 18 years, there was a pronounced association between SUA and HTG. SUA could serve as a risk indicator for HTG. It is recommended that children diagnosed with HTG should be regularly tested for SUA levels. In addition, it is recommended that SUA be included in the comprehensive care of children diagnosed with HTG.
尿酸（UA）是一种肝脏衍生的代谢物，与代谢紊乱密切相关。尽管大量研究强调了它与高三酰甘油血症（HTG）的关系，但针对青少年的研究仍然有限。为了填补流行病学方面的空白，本研究重点分析了美国青少年人群中尿酸水平与 HTG 之间的关系。
本研究共纳入了 2011 年至 2020 年通过国家健康和营养检查调查（NHANES）的 4435 名参与者。暴露变量为血清尿酸（SUA），效应变量为 HTG，协变量包括人口统计学、问卷、体检和实验室指标。我们利用加权逻辑回归和细致的亚组评估来辨别 SUA 和 HTG 之间的内在联系。分层分析增强了这种关联的验证，而平滑曲线拟合则探测了潜在的非线性相关性。
研究纳入了 4435 名参与者。男性青少年的 SUA 水平升高。在调整所有变量后，加权多元逻辑回归模型显示 SUA 与 HTG 风险呈正相关（OR=1.006，95%CI：1.005-1.007）。这种关系在 SUA 的三个三分位组中是一致的（T1：OR=1.006 [95%CI：1.005-1.007]；T2：OR=1.006 [95%CI：1.005-1.007]；T3：OR=1.004 [95%CI：1.003-1.006]；P 趋势<0.001）。分层分析证实，SUA 与 HTG 风险之间的正相关性是显著的，无论性别、年龄或种族如何。
在 12 至 18 岁的美国儿童和青少年中，SUA 与 HTG 之间存在显著关联。SUA 可作为 HTG 的风险指标。建议对诊断为 HTG 的儿童定期检测 SUA 水平。此外，建议将 SUA 纳入诊断为 HTG 的儿童的综合治疗中。
