Fan Shang-rong, Liu Xiao-ping, Li Jian-wu, Xu An-ping, Liu Miao
Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen 518036, China.
Zhonghua Fu Chan Ke Za Zhi. 2005 Aug;40(8):532-5.
To determine the clinical manifestations of vulvovaginal candidiasis (VVC) and to study the mycologic eradication rate of different miconazole treatment courses for VVC.
Three hundred cases of VVC were recruited. The Candidas were cultured. A prospective and randomized study was performed to compare the treatment effect of 3 day miconazole (400 mg/d), 6 day miconazole (400 mg/d), and 7 day miconazole (200 mg/d) for uncomplicated and complicated VVC.
Among 300 cases of VVC, uncomplicated, complicated and recurrent VVC were 56.0%, 44.0% and 9.7% (29/300) respectively. C. albicans was isolated most frequently 90.3% (271/300), followed by C. glabrata (7.3%), C. tropicalis (1.3%), C. krusei (0.7%), and C. parapsilosis (0.3 %). Mycologic eradication rate of 3 day, 6 day and 7 day miconazole courses for uncomplicated VVC at day 14 was 96.0%, 93.5% and 98.0%, respectively (P > 0.05). Eradication rate of 3 day, 6 day and 7 day miconazole courses for complicated VVC at day 14 was 86.7%, 92.5%, and 86.4%, respectively (P > 0.05). Eradication rate of 3 day, 6 day and 7 day miconazole courses for uncomplicated VVC at day 35 was 93.8%, 95.3%, and 89.8%, respectively (P > 0.05). Eradication rate of 3 day, 6 day and 7 day miconazole courses for complicated VVC at day 35 was 89.7%, 97.3% and 86.8%, respectively (P > 0.05).
Treatment of VVC should be individualized, and women with complicated VVC achieve superior mycologic eradication by a 6 day miconazole course.
确定外阴阴道念珠菌病（VVC）的临床表现，并研究不同疗程咪康唑治疗VVC的真菌清除率。
招募300例VVC患者。进行念珠菌培养。开展一项前瞻性随机研究，比较3天疗程咪康唑（400mg/d）、6天疗程咪康唑（400mg/d）和7天疗程咪康唑（200mg/d）治疗单纯性和复杂性VVC的效果。
300例VVC患者中，单纯性、复杂性和复发性VVC分别占56.0%、44.0%和9.7%（29/300）。白色念珠菌分离率最高，为90.3%（271/300），其次是光滑念珠菌（7.3%）、热带念珠菌（1.3%）、克柔念珠菌（0.7%）和近平滑念珠菌（0.3%）。单纯性VVC患者在第14天时，3天、6天和7天咪康唑疗程的真菌清除率分别为96.0%、93.5%和98.0%（P>0.05）。复杂性VVC患者在第14天时，3天、6天和7天咪康唑疗程的清除率分别为86.7%、92.5%和86.4%（P>0.05）。单纯性VVC患者在第35天时，3天、6天和7天咪康唑疗程的清除率分别为93.8%、95.3%和89.8%（P>0.05）。复杂性VVC患者在第35天时，3天、6天和7天咪康唑疗程的清除率分别为89.7%、97.3%和86.8%（P>0.05）。
VVC的治疗应个体化，对于复杂性VVC患者，6天疗程的咪康唑治疗真菌清除效果更佳。
