Comella C L, Tanner C M, DeFoor-Hill L, Smith C
Department of Neurological Sciences, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612.
Neurology. 1992 Jul;42(7):1307-10. doi: 10.1212/wnl.42.7.1307.
We prospectively evaluated the frequency, severity, and radiologic features of swallowing abnormalities following Botox treatment of spasmodic torticollis. We performed both clinical and radiologic evaluations of swallowing before and following Botox in 18 consecutive cervical dystonia patients receiving their first Botox treatment. Before Botox, 11% of the patients had clinical symptoms of dysphagia and 22% had radiologic signs of a peristaltic abnormality. After Botox, the signs and symptoms of dysphagia in these patients did not change, but an additional 33% developed new dysphagic symptoms and 50% of the patients developed new peristaltic abnormalities by radiologic studies. Complaints of swallowing difficulty were always associated with abnormal radiologic findings. Neither the total Botox dose nor Botox into particular muscles differed between those with dysphagia and those without.
我们前瞻性地评估了肉毒杆菌毒素治疗痉挛性斜颈后吞咽异常的频率、严重程度和放射学特征。我们对18例首次接受肉毒杆菌毒素治疗的连续性颈部肌张力障碍患者在注射肉毒杆菌毒素前后进行了吞咽的临床和放射学评估。在注射肉毒杆菌毒素之前,11%的患者有吞咽困难的临床症状,22%有蠕动异常的放射学征象。注射肉毒杆菌毒素后,这些患者吞咽困难的体征和症状没有改变,但另有33%出现了新的吞咽困难症状,50%的患者经放射学研究出现了新的蠕动异常。吞咽困难的主诉总是与异常的放射学表现相关。有吞咽困难和无吞咽困难的患者之间,肉毒杆菌毒素的总剂量以及注入特定肌肉的肉毒杆菌毒素剂量均无差异。