来自巴西苦楝的细胞毒性柠檬苦素。
Cytotoxic limonoids from Brazilian Melia azedarach.
作者信息
Zhou Honglei, Hamazaki Atsuko, Fontana Jose Domingos, Takahashi Hironobu, Wandscheer Carolina Bueno, Fukuyama Yoshiyasu
机构信息
Institute of Pharmacognosy, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
出版信息
Chem Pharm Bull (Tokyo). 2005 Oct;53(10):1362-5. doi: 10.1248/cpb.53.1362.
Three new C-seco limonoids (1-3) and one new tetracyclic limonoid (4) were isolated from a methanol extract of the ripe fruits of Melia azedarach collected in Curitiba, Brazil, and their structures were elucidated by spectroscopic data analysis and comparison of spectral data with those of the previously known compounds. Among the limonoids isolated in the present study, compounds 3 and 4 exhibited significant inhibitory activity against HeLa S3 cancer cells, whereas 1 and 2 showed weak cytotoxicity.
从巴西库里蒂巴收集的苦楝成熟果实的甲醇提取物中分离出三种新的C-裂环柠檬苦素（1-3）和一种新的四环柠檬苦素（4），并通过光谱数据分析以及将光谱数据与先前已知化合物的数据进行比较来阐明它们的结构。在本研究中分离出的柠檬苦素中，化合物3和4对HeLa S3癌细胞表现出显著的抑制活性，而1和2显示出较弱的细胞毒性。
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