苦楝果实中的细胞毒性三萜类化合物。

Pesticide Science Laboratory, Faculty of Agriculture, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.

Molecules. 2010 Aug 27;15(9):5866-77. doi: 10.3390/molecules15095866.

The phytochemical investigation of the dichloromethane-soluble part of the methanol extract obtained from the fruits of Melia azedarach afforded one new tirucallane-type triterpene, 3-alpha-tigloylmelianol and three known tirucallanes, melianone, 21-beta-acetoxy-melianone, and methyl kulonate. The structure of the isolated compounds was mainly determined by 1D and 2D NMR experiments as well as HPLC-Q-TOF mass spectrometry. The cytotoxicity of the isolated compounds toward the human lung adenocarcinoma epithelial cell line A549 was determined, while no activity was observed against the phytonematode Meloidogyne incognita.

从苦楝果实的甲醇提取物的二氯甲烷可溶部分进行植物化学成分研究，得到了一种新的三萜类化合物，3-α- 齐墩果酸基苦楝醇和三种已知的三萜类化合物，苦楝酮、21-β- 乙酰氧基苦楝酮和甲基库尔酮。分离得到的化合物的结构主要通过 1D 和 2D NMR 实验以及高效液相色谱-四极杆飞行时间质谱确定。测定了分离得到的化合物对人肺腺癌细胞系 A549 的细胞毒性，而对植物线虫根结线虫没有活性。