从巴西苦楝中分离得到的新型C-环裂柠檬苦素类化合物及其细胞毒性活性。

New ring C-seco limonoids from Brazilian Melia azedarach and their cytotoxic activity.

作者信息

Zhou Honglei, Hamazaki Atsuko, Fontana Jose Domingos, Takahashi Hironobu, Esumi Tomoyuki, Wandscheer Carolina Bueno, Tsujimoto Hiroaki, Fukuyama Yoshiyasu

机构信息

Institute of Pharmacognosy, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.

出版信息

J Nat Prod. 2004 Sep;67(9):1544-7. doi: 10.1021/np040077r.

DOI:10.1021/np040077r

PMID:15387656

Abstract

A methanol extract of the ripe fruits of Melia azedarach collected in Curitiba, Parana, Brazil, afforded seven new ring C-seco limonoids (1-7) together with three known limonoids (8-10). The structures of the new compounds were elucidated by NMR and MS analysis and comparison of spectral data with those of previously known compounds. Compounds 4 and 5 exhibited significant inhibitory activity against HeLa S3 cancer cells, whereas 1, 2, 3, and 8 showed weak cytotoxicity.

摘要

从巴西巴拉那州库里蒂巴采集的苦楝成熟果实的甲醇提取物中，得到了7种新的C环裂环柠檬苦素（1-7）以及3种已知的柠檬苦素（8-10）。通过核磁共振（NMR）和质谱（MS）分析，并将光谱数据与先前已知化合物的数据进行比较，阐明了新化合物的结构。化合物4和5对HeLa S3癌细胞表现出显著的抑制活性，而化合物1、2、3和8显示出较弱的细胞毒性。