van der Heijde Désirée M F M, Landewé Robert B M, Hermann Kay-Geert A, Jurik Anne-Grethe, Maksymowych Walter P, Rudwaleit Martin, O'Connor Philip J, Braun Jürgen
Department of Internal Medicine, Division of Rheumatology, University Hospital Maastricht, University Maastricht, 6202 AZ Maastricht, The Netherlands.
J Rheumatol. 2005 Oct;32(10):2042-7.
Magnetic resolution imaging (MRI) is a promising tool in the assessment of inflammation and structural damage in clinical trials in ankylosing spondylitis (AS). The ASAS/OMERACT MRI in AS working group, a collaborative initiative of rheumatologists and musculoskeletal radiologists with a special interest in this field, collected data on all available scoring methods for both sacroiliac (SI) joints and spine, and tested them with respect to the OMERACT filter. These data were presented together with the technical specifications of all methods at the OMERACT 7 conference. In addition, the results of 2 separate experiments on the inter-reader reliability of scoring methods to assess activity in SI joints, and on the comparison of STIR sequence versus T1 post-gadolinium (Gd) sequence for the spine, were presented. Thereafter, 8 groups discussed these data and proposed a research agenda, each on a different topic. This information was reported back to all participants and a prioritized research agenda was compiled by voting. Research on scoring methods for assessing disease activity, in both the spine and SI joints, was considered most important. Research on assessing structural damage was considered less important. The specific process and results of this initiative are discussed.
磁分辨率成像（MRI）在强直性脊柱炎（AS）临床试验中评估炎症和结构损伤方面是一种很有前景的工具。ASAS/OMERACT AS MRI工作组是风湿病学家和对该领域特别感兴趣的肌肉骨骼放射科医生的合作项目，收集了有关骶髂（SI）关节和脊柱所有可用评分方法的数据，并根据OMERACT标准对其进行了测试。这些数据与所有方法的技术规范一起在OMERACT 7会议上公布。此外，还公布了关于评分方法评估SI关节活动度的阅片者间可靠性以及脊柱短TI反转恢复（STIR）序列与钆（Gd）增强T1序列比较的两项独立实验结果。此后，8个小组讨论了这些数据并提出了研究议程，每个小组关注不同主题。这些信息反馈给了所有参与者，并通过投票编制了优先研究议程。评估脊柱和SI关节疾病活动度评分方法的研究被认为最为重要。评估结构损伤的研究被认为重要性稍低。本文讨论了该项目的具体过程和结果。
