Chen Raymond E, Thorner Jeremy
Division of Biochemistry and Molecular Biology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3202, USA.
Genome Biol. 2005;6(10):235. doi: 10.1186/gb-2005-6-10-235. Epub 2005 Sep 29.
The use of methods for global and quantitative analysis of cells is providing new systems-level insights into signal transduction processes. Recent studies reveal important information about the rates of signal transmission and propagation, help establish some general regulatory characteristics of multi-tiered signaling cascades, and illuminate the combinatorial nature of signaling specificity in cell differentiation.
细胞全局和定量分析方法的应用正在为信号转导过程提供新的系统层面见解。最近的研究揭示了有关信号传递和传播速率的重要信息，有助于确立多层信号级联反应的一些一般调控特征，并阐明细胞分化中信号特异性的组合性质。
