Thored Pär, Arvidsson Andreas, Cacci Emanuele, Ahlenius Henrik, Kallur Therése, Darsalia Vladimer, Ekdahl Christine T, Kokaia Zaal, Lindvall Olle
Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE-221 84 Lund, Sweden.
Stem Cells. 2006 Mar;24(3):739-47. doi: 10.1634/stemcells.2005-0281. Epub 2005 Oct 6.
Neural stem cells in the subventricular zone of adult rodents produce new striatal neurons that may replace those that have died after stroke; however, the neurogenic response has been considered acute and transient, yielding only small numbers of neurons. In contrast, we show herein that striatal neuroblasts are generated without decline at least for 4 months after stroke in adult rats. Neuroblasts formed early or late after stroke either differentiate into mature neurons, which survive for several months, or die through caspase-mediated apoptosis. The directed migration of the new neurons toward the ischemic damage is regulated by stromal cell-derived factor-1alpha and its receptor CXCR4. These results show that endogenous neural stem cells continuously supply the injured adult brain with new neurons, which suggests novel self-repair strategies to improve recovery after stroke.
成年啮齿动物脑室下区的神经干细胞可产生新的纹状体神经元，这些神经元可能替代中风后死亡的神经元；然而，神经发生反应被认为是急性且短暂的，仅产生少量神经元。相比之下，我们在此表明，成年大鼠中风后至少4个月内，纹状体神经母细胞的生成没有减少。中风后早期或晚期形成的神经母细胞要么分化为存活数月的成熟神经元，要么通过半胱天冬酶介导的凋亡而死亡。新神经元向缺血损伤部位的定向迁移受基质细胞衍生因子-1α及其受体CXCR4的调节。这些结果表明，内源性神经干细胞持续为受损的成年大脑提供新的神经元，这提示了改善中风后恢复的新型自我修复策略。
