Bouillanne Olivier, Morineau Gilles, Dupont Claire, Coulombel Isabelle, Vincent Jean-Pierre, Nicolis Ioannis, Benazeth Simone, Cynober Luc, Aussel Christian
Services de Gérontologie 2 and Biologie de la Nutrition EA2498, Université Paris 5, Paris, France.
Am J Clin Nutr. 2005 Oct;82(4):777-83. doi: 10.1093/ajcn/82.4.777.
Patients at risk of malnutrition and related morbidity and mortality can be identified with the Nutritional Risk Index (NRI). However, this index remains limited for elderly patients because of difficulties in establishing their normal weight.
Therefore, we replaced the usual weight in this formula by ideal weight according to the Lorentz formula (WLo), creating a new index called the Geriatric Nutritional Risk Index (GNRI).
First, a prospective study enrolled 181 hospitalized elderly patients. Nutritional status [albumin, prealbumin, and body mass index (BMI)] and GNRI were assessed. GNRI correlated with a severity score taking into account complications (bedsores or infections) and 6-mo mortality. Second, the GNRI was measured prospectively in 2474 patients admitted to a geriatric rehabilitation care unit over a 3-y period.
The severity score correlated with albumin and GNRI but not with BMI or weight:WLo. Risk of mortality (odds ratio) and risk of complications were, respectively, 29 (95% CI: 5.2, 161.4) and 4.4 (95% CI: 1.3, 14.9) for major nutrition-related risk (GNRI: <82), 6.6 (95% CI: 1.3, 33.0), 4.9 (95% CI: 1.9, 12.5) for moderate nutrition-related risk (GNRI: 82 to <92), and 5.6 (95% CI: 1.2, 26.6) and 3.3 (95% CI: 1.4, 8.0) for a low nutrition-related risk (GNRI: 92 to < or =98). Accordingly, 12.2%, 31.4%, 29.4%, and 27.0% of the 2474 patients had major, moderate, low, and no nutrition-related risk, respectively.
GNRI is a simple and accurate tool for predicting the risk of morbidity and mortality in hospitalized elderly patients and should be recorded systematically on admission.
营养不良及相关发病和死亡风险的患者可通过营养风险指数(NRI)来识别。然而,由于难以确定老年患者的正常体重,该指数对老年患者仍有局限性。
因此,我们用根据洛伦兹公式(WLo)计算的理想体重替代该公式中的通常体重,创建了一个名为老年营养风险指数(GNRI)的新指数。
首先,一项前瞻性研究纳入了181例住院老年患者。评估了营养状况[白蛋白、前白蛋白和体重指数(BMI)]及GNRI。GNRI与考虑并发症(褥疮或感染)和6个月死亡率的严重程度评分相关。其次,在3年期间对2474例入住老年康复护理单元的患者进行了前瞻性GNRI测量。
严重程度评分与白蛋白和GNRI相关,但与BMI或体重:WLo无关。对于主要营养相关风险(GNRI:<82),死亡风险(比值比)和并发症风险分别为29(95%CI:5.2,161.4)和4.4(95%CI:1.3,14.9);对于中度营养相关风险(GNRI:82至<92),分别为6.6(95%CI:1.3,33.0)和4.9(95%CI:1.9,12.5);对于低营养相关风险(GNRI:92至<或=98),分别为5.6(95%CI:1.2,26.6)和3.3(95%CI:1.4,8.0)。因此,2474例患者中分别有12.2%、31.4%、29.4%和27.0%存在主要、中度、低度和无营养相关风险。
GNRI是预测住院老年患者发病和死亡风险的简单准确工具,应在入院时系统记录。