Nagler-Anderson Cathryn
Mucosal Immunology Laboratory, Massachusetts General Hospital, Charlestown, Mass., USA.
Chem Immunol Allergy. 2006;90:1-13. doi: 10.1159/000088876.
Work from our laboratory has shown that an enteric helminth infection can act as an adjuvant to prime for a Th2-biased response to a typically tolerogenic form of dietary antigen. Helminth infection did not, however, prime for an allergic response. Using a model in which systemic anaphylactic symptoms and antigen specific IgE are induced in C3H/HeJ mice by repeated intragastric administration of peanut antigen with the mucosal adjuvant cholera toxin we showed that an enteric helminth infection protects against the development of food allergy. Helminth-dependent protection against allergy was abrogated when the helminth-infected, allergen-sensitized mice were treated with neutralizing antibodies to IL-10. Recent work from our laboratory and others has implicated helminth induced immunoregulatory cells in protection against allergy. We will discuss the characteristics of the immunoregulatory cell populations that have been described and the mechanism(s) by which they may function in the suppression of allergy.
我们实验室的研究表明，肠道蠕虫感染可作为一种佐剂，引发对通常具有耐受性的饮食抗原的Th2偏向性反应。然而，蠕虫感染并不会引发过敏反应。在一个通过向C3H/HeJ小鼠反复胃内注射花生抗原及黏膜佐剂霍乱毒素来诱导全身过敏症状和抗原特异性IgE的模型中，我们发现肠道蠕虫感染可预防食物过敏的发生。当用抗IL-10中和抗体处理感染蠕虫且对过敏原致敏的小鼠时，蠕虫依赖的过敏保护作用被消除。我们实验室及其他机构最近的研究表明，蠕虫诱导的免疫调节细胞参与了过敏保护作用。我们将讨论已描述的免疫调节细胞群体的特征及其在抑制过敏中可能发挥作用的机制。
