Punzi L, Ostuni P A, Betterle C, De Sandre P, Botsios C, Gambari P F
Department of Rheumatology, Padua University, Italy.
Rev Rhum Engl Ed. 1996 Dec;63(11):809-14.
To evaluate the frequency of thyroid disorders in primary Sjögen's syndrome.
121 consecutive patients meeting Vitali's criteria for primary Sjögren's syndrome and 74 with rheumatoid arthritis underwent thyroid hormone assays, tests for antimicrosomal and antithyroglobulin antibodies, tests for antinuclear antibodies and antibodies to extractable nuclear antigens. Antimicrosomal and antithyroglobulin antibodies were also assayed in 404 controls.
frequencies were calculated separately in males and females, and data in females were subjected to statistical analysis. As compared with controls, Sjögren's syndrome patients were more likely to have antimicrosomal antibodies (9% versus 17.6%, P < 0.05) and both Sjögren's syndrome and rheumatoid arthritis patients were more likely to have antithyroglobulin antibodies (1% versus 13.4% and 10.9%, respectively, P < 0.0001). Hypothyroidism was more common among Sjögren's syndrome patients (13.4%) than rheumatoid arthritis patients (3.1%) (P < 0.05). Sjögren's syndrome patients with thyroid disorders were less likely to have antinuclear antibodies, rheumatoid factors or a Chisholm's stage 3 or 4 lip biopsy.
our data confirm that thyroid disorders are more common in primary Sjögren's syndrome than in rheumatoid arthritis and controls. Production of autoantibodies and severe histologic lesions were less common in Sjögren's syndrome patients with than without thyroid disorders.
评估原发性干燥综合征患者甲状腺疾病的发生率。
121例符合维塔利原发性干燥综合征标准的连续患者以及74例类风湿关节炎患者接受了甲状腺激素检测、抗微粒体和抗甲状腺球蛋白抗体检测、抗核抗体检测以及可提取核抗原抗体检测。还对404名对照者进行了抗微粒体和抗甲状腺球蛋白抗体检测。
分别计算男性和女性的发生率，并对女性数据进行统计分析。与对照组相比，干燥综合征患者更易出现抗微粒体抗体（9% 对17.6%，P < 0.05），干燥综合征患者和类风湿关节炎患者均更易出现抗甲状腺球蛋白抗体（分别为1% 对13.4% 和10.9%，P < 0.0001）。甲状腺功能减退在干燥综合征患者中（13.4%）比类风湿关节炎患者中（3.1%）更常见（P < 0.05）。患有甲状腺疾病的干燥综合征患者出现抗核抗体、类风湿因子或奇泽姆3期或4期唇活检的可能性较小。
我们的数据证实，原发性干燥综合征患者比类风湿关节炎患者和对照者更易出现甲状腺疾病。与无甲状腺疾病的干燥综合征患者相比，患有甲状腺疾病的患者产生自身抗体和出现严重组织学病变的情况较少见。
