Choi Sang Zin, Lee Sung Ok, Jang Ki Uk, Chung Sung Hyun, Park Sang Hyun, Kang Hee Chol, Yang Eun Young, Cho Hi Jae, Lee Kang Ro
Natural Products Laboratory, College of Pharmacy, SungKyunKwan University, Suwon 440-746, Korea.
Arch Pharm Res. 2005 Sep;28(9):1027-30. doi: 10.1007/BF02977396.
The antidiabetic-activity-guided fractionation and isolation of the 80% EtOH extracts obtained from cultivated Korean Rhubarb rhizomes (Rheum undulatum, Polygonaceae) led to the isolation and characterization of one stilbene, desoxyrhapontigenin (1) and two anthraquinones, emodin (2) and chrysophanol (3). Their structures were established by chemical and spectroscopic methods. Compounds 1, 2, and 3 inhibited postprandial hyperglycemia by 35.8, 29.5, 42.3%, respectively.
对栽培的朝鲜大黄根茎（掌叶大黄，蓼科）所得80%乙醇提取物进行抗糖尿病活性导向的分馏和分离，得到一种芪类化合物去氧白藜芦醇（1）、两种蒽醌类化合物大黄素（2）和大黄酚（3）。通过化学和光谱方法确定了它们的结构。化合物1、2和3分别使餐后高血糖降低35.8%、29.5%、42.3%。
