Xie Wen-Li, Lu Zheng-Yang, Xu Jing, Chen Yu, Teng Hong-Li, Yang Guang-Zhong
Ethnopharmacology Level 3 Laboratory, School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, P. R. China.
College of Chemistry and Material Sciences, South-Central Minzu University, Wuhan 430074, P. R. China.
ACS Omega. 2024 Jan 5;9(3):3942-3949. doi: 10.1021/acsomega.3c08357. eCollection 2024 Jan 23.
One previously undescribed naphthoquinone-benzisochromanquinone dimer berpolydiquinone A (), along with two previously undescribed naphthoquinone-anthraquinone dimers berpolydiquinones B and C (-), and one previously undescribed dimeric naphthalene berpolydinaphthalene A (), were isolated from the stems and leaves of var. leioclada. The chemical structures of these compounds were determined using high-resolution electrospray ionization mass spectroscopy (HR-ESI-MS), spectroscopic data, the exciton chirality method (ECM), and quantum chemical calculation. Notably, compounds (- and ) are dimeric quinones that share the same naphthoquinone moiety, specifically identified as 2-methoxystypandron. Compound () is a derivative of dimeric naphthalene with a symmetrical structure, which is a new structure type isolated from var. leioclada for the first time. These findings suggest that var. leioclada serves as a significant reservoir of structurally diverse phenolic compounds. This study provides a scientific foundation for regarding var. leioclada as a potential source of "Tiebaojin".
从光枝勾儿茶变种的茎和叶中分离出一种先前未描述的萘醌 - 苯并异色满醌二聚体berpolydiquinone A（），以及两种先前未描述的萘醌 - 蒽醌二聚体berpolydiquinones B和C（ - ），和一种先前未描述的二聚萘berpolydinaphthalene A（）。这些化合物的化学结构通过高分辨率电喷雾电离质谱（HR - ESI - MS）、光谱数据、激子手性方法（ECM）和量子化学计算来确定。值得注意的是，化合物（ - 和 ）是具有相同萘醌部分的二聚醌，具体鉴定为2 - 甲氧基斯替潘酮。化合物（）是具有对称结构的二聚萘衍生物，这是首次从光枝勾儿茶变种中分离出的一种新结构类型。这些发现表明光枝勾儿茶变种是结构多样的酚类化合物的重要储存库。本研究为将光枝勾儿茶变种视为“铁包金”的潜在来源提供了科学依据。
