Zhang Yong Liang, Dong Chen
Department of Immunology, MD Anderson Cancer Center, University of Texas, Houston, 77030, USA.
Cell Mol Immunol. 2005 Feb;2(1):20-7.
MAP kinases are evolutionarily conserved signaling regulators from budding yeast to mammals and play essential roles in both innate and adaptive immune responses. There are three main families of MAPKs in mammals. Each of them has its own activators, inactivators, substrates and scaffolds, which altogether form a fine signaling network in response to different extracellular or intracellular stimulation. In this review, we summarize recent advances in understanding of the regulation of MAP kinases and the roles of MAP kinases in innate and adaptive immune responses.
丝裂原活化蛋白激酶（MAP激酶）是从芽殖酵母到哺乳动物进化上保守的信号调节因子，在先天免疫和适应性免疫反应中都发挥着重要作用。哺乳动物中有三个主要的MAPK家族。它们各自都有自己的激活剂、失活剂、底物和支架蛋白，这些共同构成了一个精细的信号网络，以响应不同的细胞外或细胞内刺激。在本综述中，我们总结了对MAP激酶调控的理解以及MAP激酶在先天免疫和适应性免疫反应中的作用的最新进展。
