Smith Christopher W J
Department of Biochemistry, Cambridge, UK.
Cell. 2005 Oct 7;123(1):1-3. doi: 10.1016/j.cell.2005.09.010.
Various mechanisms have been proposed to explain mutually exclusive splicing of pairs of exons. A paper in this issue of Cell (Graveley, 2005) provides a fascinating insight into the perplexing question of how only one exon at a time is chosen from an array of 48 exons in the Drosophila Dscam gene.
人们已经提出了各种机制来解释外显子对的互斥剪接。发表在本期《细胞》杂志上的一篇论文(Graveley,2005年),就果蝇Dscam基因中如何从48个外显子阵列中一次仅选择一个外显子这个令人困惑的问题,提供了饶有趣味的见解。