Hesse Swen, Müller Ulrich, Lincke Thomas, Barthel Henryk, Villmann Thomas, Angermeyer Matthias C, Sabri Osama, Stengler-Wenzke Katarina
Department of Nuclear Medicine, University of Leipzig, Stephanstrasse 11, D-04103 Leipzig, Germany.
Psychiatry Res. 2005 Oct 30;140(1):63-72. doi: 10.1016/j.pscychresns.2005.07.002. Epub 2005 Oct 6.
In obsessive-compulsive disorder (OCD), the success of pharmacological treatment with serotonin re-uptake inhibitors and atypical antipsychotic drugs suggests that both the central serotonergic and dopaminergic systems are involved in the pathophysiology of the disorder. We applied [123I]-2beta-carbomethoxy-3beta-(4-idiophenyl)tropane (beta-CIT) and a brain-dedicated high-resolution single photon emission computed tomography (SPECT) system to quantify dopamine transporter (DAT) and serotonin transporter (SERT) availability. By comparing 15 drug-naïve patients with OCD and 10 controls, we found a significantly reduced availability (corrected for age) of striatal DAT and of thalamic/hypothalamic, midbrain and brainstem SERT in OCD patients. Severity of OCD symptoms showed a significant negative correlation with thalamic/hypothalamic SERT availability, corrected for age and duration of symptoms. Our data provide evidence for imbalanced monoaminergic neurotransmitter modulation in OCD. Further studies with more selective DAT and SERT radiotracers are needed.
在强迫症（OCD）中，5-羟色胺再摄取抑制剂和非典型抗精神病药物的药物治疗成功表明，中枢5-羟色胺能和多巴胺能系统均参与该疾病的病理生理过程。我们应用[123I]-2β-甲氧羰基-3β-（4-碘苯基）托烷（β-CIT）和脑部专用高分辨率单光子发射计算机断层扫描（SPECT）系统来量化多巴胺转运体（DAT）和5-羟色胺转运体（SERT）的可用性。通过比较15例未接受过药物治疗的强迫症患者和10例对照者，我们发现强迫症患者纹状体DAT以及丘脑/下丘脑、中脑和脑干SERT的可用性（经年龄校正）显著降低。强迫症症状的严重程度与经年龄和症状持续时间校正后的丘脑/下丘脑SERT可用性呈显著负相关。我们的数据为强迫症中单胺能神经递质调节失衡提供了证据。需要使用更具选择性的DAT和SERT放射性示踪剂进行进一步研究。
