Boehm Günther, Stahl Bernd, Jelinek Jürgen, Knol Jan, Miniello Vito, Moro Guido E
Numico Research, Friedrichsdorf, Germany.
Acta Paediatr Suppl. 2005 Oct;94(449):18-21. doi: 10.1111/j.1651-2227.2005.tb02149.x.
Human milk oligosaccharides play an important role, as prebiotic soluble fibres, in the postnatal development of the intestinal flora. Infant formulas are virtually free of prebiotic oligosaccharides. As a consequence, formula-fed infants develop an intestinal flora significantly different to the flora of breastfed infants. Due to the complexity of human milk oligosaccharides, it is necessary to use alternative sources of prebiotic ingredients as components of infant formulas. The present review summarizes the data of experimental research and clinical studies with a prebiotic mixture containing 90% short-chain galacto-oligosaccharides and 10% long-chain fructo-oligosacchrides are summarized. The data demonstrate that, with this prebiotic mixture, the growth of bifidobacteria and lactobacilli can be stimulated, the faecal pH can be decreased, and the presence of pathogens can be reduced to levels similar to those of breastfed infants. Thus, prebiotic oligosaccharides such as the studied mixture provide beneficial effects for formula-fed infants.
人乳寡糖作为益生元可溶性纤维，在肠道菌群的产后发育中发挥着重要作用。婴儿配方奶粉几乎不含益生元寡糖。因此，用配方奶粉喂养的婴儿所形成的肠道菌群与母乳喂养婴儿的菌群有显著差异。由于人乳寡糖的复杂性，有必要使用替代来源的益生元成分作为婴儿配方奶粉的组成部分。本综述总结了含90%短链低聚半乳糖和10%长链低聚果糖的益生元混合物的实验研究和临床研究数据。数据表明，使用这种益生元混合物可刺激双歧杆菌和乳酸杆菌的生长，降低粪便pH值，并将病原体数量减少到与母乳喂养婴儿相似的水平。因此，像所研究的混合物这样的益生元寡糖可为用配方奶粉喂养的婴儿带来有益效果。
