马里兰州队列男性中输精管切除术与前列腺癌的关联。

Association of vasectomy and prostate cancer among men in a Maryland cohort.

作者信息

Rohrmann Sabine, Paltoo Dina N, Platz Elizabeth A, Hoffman Sandra C, Comstock George W, Helzlsouer Kathy J

机构信息

Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, 615 N. Wolfe St., Room E6138, Baltimore, MD 21205, USA.

出版信息

Cancer Causes Control. 2005 Dec;16(10):1189-94. doi: 10.1007/s10552-005-0304-8.

DOI:10.1007/s10552-005-0304-8

PMID:16215869

Abstract

OBJECTIVES

To evaluate the association of vasectomy with prostate cancer.

METHODS

Participants were male members of the CLUE II cohort followed since 1989. On a questionnaire mailed in 1996, the men were asked if they had had a vasectomy and their age at vasectomy. Between 1996 and April 2004, 78 prostate cancer cases were confirmed among the 3373 men who were at least 35 years old at baseline and who completed the questions about vasectomy. Cox proportional hazards regression was used to estimate age-adjusted hazard ratios (HR) of prostate cancer.

RESULTS

The HR for prostate cancer for men who had had a vasectomy was 2.03 (95% CI: 1.24-3.32). Risk of low-grade disease (HR=2.87; 95% CI 1.49-5.54), but not high-grade disease (HR=0.99; 95% CI 0.36-2.76), was higher in men who had had a vasectomy. No statistically significant associations were observed for low- or high-stage disease. The association for vasectomy was more pronounced in men who were 40 years at the time of vasectomy (HR=2.63; 95% CI 1.40-4.94) than in men who were younger at vasectomy.

CONCLUSIONS

The results from this prospective study suggest a positive association between vasectomy and prostate cancer, especially low-grade disease.

摘要

目的

评估输精管切除术与前列腺癌之间的关联。

方法

研究对象为自1989年起随访的CLUE II队列中的男性成员。在1996年邮寄的一份问卷中，询问这些男性是否进行过输精管切除术以及输精管切除时的年龄。在1996年至2004年4月期间，在3373名基线时至少35岁且完成了关于输精管切除术问题的男性中，确诊了78例前列腺癌病例。采用Cox比例风险回归来估计前列腺癌的年龄调整风险比（HR）。

结果

进行过输精管切除术的男性患前列腺癌的HR为2.03（95%置信区间：1.24 - 3.32）。进行过输精管切除术的男性患低级别疾病的风险较高（HR = 2.87；95%置信区间1.49 - 5.54），但高级别疾病的风险不高（HR = 0.99；95%置信区间0.36 - 2.76）。对于低分期或高分期疾病，未观察到统计学上显著的关联。输精管切除术与前列腺癌的关联在输精管切除时年龄为40岁的男性中（HR = 2.63；95%置信区间1.40 - 4.94）比输精管切除时年龄较小的男性更为明显。