Tootla R, Kotru G, Connolly M A, Duggal M S, Toumba K J
Dept. Paediatric Dentistry, Leeds Dental Institute, England.
Eur J Paediatr Dent. 2005 Sep;6(3):139-43.
The purpose of this pilot study was to identify the subsurface enamel demineralising potential of two possible acidogenic lactose-based powders and their corresponding generic pump inhalers.
Ten healthy non-asthmatic adults participated in a 5- leg randomised crossover study including a 10% sucrose control. A twice-daily 400 microg dose of inhaler was applied in vitro to a demineralised enamel slab on the buccal flange of a mandibular removable appliance before in situ placement for 14 days each. Lesion parameters were determined using transverse microradiography and digitised image analysis.
Minimal demineralisation occurred with sucrose, both pump and one powder inhaler. The remaining powder was associated with remineralisation (p = 0.29). Overall, mean lesion depth increased (p = 0.12).
Asthma inhalers failed to demonstrate a significant acidogenic/cariogenic effect.
本初步研究的目的是确定两种可能产酸的乳糖基粉末及其相应的普通泵式吸入器对牙釉质表面下脱矿的潜在影响。
10名健康的非哮喘成年人参与了一项包含5个阶段的随机交叉研究，其中包括10%蔗糖对照。每天两次400微克剂量的吸入器在体外应用于下颌可摘矫治器颊侧翼缘的脱矿牙釉质板上，然后原位放置14天。使用横向显微放射照相术和数字化图像分析确定病变参数。
蔗糖、泵式吸入器和一种粉末吸入器导致的脱矿作用最小。剩余的粉末与再矿化有关（p = 0.29）。总体而言，平均病变深度增加（p = 0.12）。
哮喘吸入器未显示出显著的产酸/致龋作用。
