Musana A Kenneth, Yale Steven H
Marshfield Clinic, 1000 N OakAve, Marshfield, WI 54449, USA.
WMJ. 2005 Aug;104(6):56-60.
To review central pontine myelinolysis (CPM) and osmotic demyelination syndrome (ODS) and describe the clinical features, etiologic factors, and clinical outcomes of 6 patients diagnosed with CPM or ODS.
A retrospective case series.
Medical records of patients diagnosed with CPM or ODS at Marshfield Clinic/St. Joseph's Hospital from 1986 to 2003 were reviewed. Chart abstraction was completed with a standardized data abstraction form.
Six patients were identified, ranging in age from 31-73 years (mean age = 51.5 years). Clinical presentations were nonspecific. Common symptoms included lethargy and dysarthria. Five of the 6 patients had chronic alcoholism. All had improvements in their clinical conditions upon hospital discharge.
CPM and ODS are rare demyelinating diseases of the pons and extrapontine sites. Prompt diagnosis and management of associated complications are essential for favorable clinical outcomes.
回顾性分析中央桥脑髓鞘溶解症（CPM）和渗透性脱髓鞘综合征（ODS），并描述6例诊断为CPM或ODS患者的临床特征、病因及临床转归。
一项回顾性病例系列研究。
回顾1986年至2003年在马什菲尔德诊所/圣约瑟夫医院诊断为CPM或ODS患者的病历。使用标准化数据提取表完成病历摘要。
共确定6例患者，年龄31 - 73岁（平均年龄 = 51.5岁）。临床表现无特异性。常见症状包括嗜睡和构音障碍。6例患者中有5例患有慢性酒精中毒。所有患者出院时临床状况均有改善。
CPM和ODS是桥脑及脑桥外部位罕见的脱髓鞘疾病。及时诊断并处理相关并发症对良好的临床转归至关重要。
