Chen Shengfu, Zheng Jie, Li Lingyan, Jiang Shaoyi
Department of Chemical Engineering, University of Washington, Seattle, WA 98195, USA.
J Am Chem Soc. 2005 Oct 19;127(41):14473-8. doi: 10.1021/ja054169u.
In this work, we show the strong resistance of zwitterionic phosphorylcholine (PC) self-assembled monolayers (SAMs) to protein adsorption and examine key factors leading to their nonfouling behavior using both experimental and molecular simulation techniques. Zwitterions with a balanced charge and minimized dipole are excellent candidates as nonfouling materials due to their strong hydration capacity via electrostatic interactions.
在本研究中，我们展示了两性离子型磷酰胆碱（PC）自组装单分子层（SAMs）对蛋白质吸附的强抗性，并使用实验和分子模拟技术研究了导致其抗污染行为的关键因素。电荷平衡且偶极最小化的两性离子因其通过静电相互作用具有很强的水合能力，是作为抗污染材料的极佳候选者。
