海洋天然产物克拉沃索利德A非对映异构体的全合成。
Total synthesis of a diastereomer of the marine natural product clavosolide A.
作者信息
Barry Conor S, Bushby Nick, Charmant Jonathan P H, Elsworth Jon D, Harding John R, Willis Christine L
机构信息
School of Chemistry, University of Bristol, Cantock's Close, Bristol, UK.
出版信息
Chem Commun (Camb). 2005 Oct 28(40):5097-9. doi: 10.1039/b509757f. Epub 2005 Sep 15.
DOI:10.1039/b509757f
PMID:16220183
Abstract
The first total synthesis of the reported structure of the sponge metabolite clavosolide A is described using a Prins cyclisation to assemble the tetrahydropyran core followed by manipulation of the side-chain, dimerisation and finally glycosidation.
摘要
本文描述了海绵代谢产物克拉沃索利德A报道结构的首次全合成，该合成采用普林斯环化反应构建四氢吡喃核心，随后对侧链进行操作、二聚化，最后进行糖苷化。
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