（+）-拉索内酯A的全合成。

Total synthesis of (+)-lasonolide A.

作者信息

Yoshimura Tomoyuki, Yakushiji Fumika, Kondo Shingo, Wu Xiaofeng, Shindo Mitsuru, Shishido Kozo

机构信息

Graduate School of Pharmaceutical Sciences, The University of Tokushima, 1-78 Sho-machi, Tokushima 770-8505, Japan.

出版信息

Org Lett. 2006 Feb 2;8(3):475-8. doi: 10.1021/ol0527678.

DOI:10.1021/ol0527678

PMID:16435863

Abstract

[structure: see text]. An enantiocontrolled total synthesis of (+)-lasonolide A has been accomplished by using the sequential cross metathesis and macrolactonization for the key assembly of the 20-membered polyene macrolide core of the natural product.

摘要

[结构：见正文]。通过使用顺序交叉复分解反应和大环内酯化反应来构建天然产物二十元多烯大环内酯核心结构，已完成了（+）-拉索内酯A的对映体控制的全合成。