Kashii T, Mizushima Y, Nakagawa K, Monno S, Yano S
First Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan.
Anticancer Res. 1992 May-Jun;12(3):621-4.
Myc gene abnormalities were studied in 30 human lung cancer cell lines. N-myc gene amplification was found in an adenocarcinoma cell line, VMRC-LCD. Neither c- or L-myc gene amplifications nor K-ras codon 12, 13, 61 point mutations were observed in this tumor. Cytomorphologically the VMRC-LCD cells had positive characteristics of typical adenocarcinoma, and the carcinoembryonic antigen in the culture medium was strongly positive. N-myc gene amplification in adenocarcinoma of the lung is extremely rare, therefore we report herein on this case.
对30个人类肺癌细胞系进行了Myc基因异常研究。在一个腺癌细胞系VMRC-LCD中发现了N-myc基因扩增。在该肿瘤中未观察到c-或L-myc基因扩增，也未观察到K-ras密码子12、13、61的点突变。细胞形态学上，VMRC-LCD细胞具有典型腺癌的阳性特征，培养基中的癌胚抗原呈强阳性。肺腺癌中的N-myc基因扩增极为罕见，因此我们在此报告该病例。
