Rucci P, Taliani G, Cirrincione L, Alberti A, Bartolozzi D, Caporaso N, Colombo M, Coppola R, Chiaramonte M, Craxi A, De Sio I, Floreani A R, Gaeta G B, Persico M, Secchi G, Versace I, Mele A
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Via Roma 67, Pisa 56100, Italy.
Dig Liver Dis. 2005 Nov;37(11):850-60. doi: 10.1016/j.dld.2005.02.014. Epub 2005 Oct 10.
The Chronic Liver Disease Questionnaire is a specific health-related quality of life assessment designed for patients with liver diseases.
The aim of this paper is to report on the validity, reliability and sensitivity to change of the Italian version (Chronic Liver Disease Questionnaire-I) in subjects with HCV infection.
The Chronic Liver Disease Questionnaire-I was administered to 350 subjects with HCV infection together with the World Health Organization Quality of Life Assessment, abbreviated version, a generic quality of life assessment.
The instrument was translated from English, backtranslated and reviewed in focus groups in the framework of a large multicentre study. Exploratory factor analysis identified five factors accounting for 65% of the variance of Chronic Liver Disease Questionnaire-I items and only partially overlapping with those found in the original version.
The Chronic Liver Disease Questionnaire-I proved to discriminate between subjects with and without comorbid diseases at baseline (t-test = 3.59, p < 0.001). Test-retest reliability was moderate (ICC = 0.60). The Chronic Liver Disease Questionnaire-I was sensitive to change in patients who deteriorated after one month of treatment. Change in the overall Chronic Liver Disease Questionnaire-I score in deteriorated patients was correlated with changes in World Health Organization Quality of Life Assessment, abbreviated version scores in the physical, psychological and environment, but not in the social area.
The Italian version of Chronic Liver Disease Questionnaire is a valid and reliable instrument to be used in cross-sectional and longitudinal studies.
慢性肝病问卷是一种专为肝病患者设计的特定健康相关生活质量评估工具。
本文旨在报告意大利语版（慢性肝病问卷-I）在丙型肝炎病毒（HCV）感染患者中的效度、信度及对变化的敏感性。
对350名HCV感染患者进行了慢性肝病问卷-I调查，并同时进行了世界卫生组织生活质量评估简表（一种通用的生活质量评估）。
该工具从英语翻译而来，经过回译，并在一项大型多中心研究框架内的焦点小组中进行了审核。探索性因素分析确定了五个因素，这些因素占慢性肝病问卷-I项目方差的65%，且仅部分与原始版本中发现的因素重叠。
慢性肝病问卷-I在基线时能够区分有无合并症的患者（t检验=3.59，p<0.001）。重测信度中等（组内相关系数=0.60）。慢性肝病问卷-I对治疗一个月后病情恶化的患者的变化敏感。病情恶化患者的慢性肝病问卷-I总分变化与世界卫生组织生活质量评估简表在生理、心理和环境领域的得分变化相关，但与社会领域的得分变化无关。
意大利语版慢性肝病问卷是一种适用于横断面和纵向研究的有效且可靠的工具。
