Völzke Henry, Robinson Daniel M, John Ulrich
Institute of Epidemiology and Social Medicine, Ernst Moritz Arndt University, Greifswald, Germany.
World J Gastroenterol. 2005 Sep 21;11(35):5530-4. doi: 10.3748/wjg.v11.i35.5530.
To investigate those associations using data of the population-based Study of Health in Pomerania.
A study population of 3 749 residents aged 20-79 years without previously diagnosed thyroid disease was available for analyses. Serum TSH was used to assess thyroid function. Cholelithiasis was defined by either a prior history of cholecystectomy or the presence of gallstones on ultrasound. Logistic regression was performed to analyze independent associations between thyroid function and cholelithiasis.
There were 385 persons (10.3%) with low (<0.3 mIU/L), 3 321 persons (88.6%) with normal and 43 persons (1.2%) with high serum TSH levels (>3 mIU/L). The proportion of cholelithiasis among males and females was 14.4% and 25.3%, respectively. Among males, there was an independent relation between high serum TSH and cholelithiasis (OR 3.77; 95%-CI 1.06-13.41; P<0.05). Also among males, there was a tendency towards an elevated risk of cholelithiasis in persons with low serum TSH (OR 1.40; 95%-CI 0.96-2.02; P = 0.07). In the female population, no such relation was identified.
There is an association between thyroid and gallstone disease with a gender-specific relation between hypothyroidism and cholelithiasis.
利用基于人群的波美拉尼亚健康研究数据调查这些关联。
研究人群为3749名年龄在20 - 79岁之间且既往未被诊断患有甲状腺疾病的居民，可用于分析。血清促甲状腺激素（TSH）用于评估甲状腺功能。胆石症的定义为既往有胆囊切除术史或超声检查发现胆结石。采用逻辑回归分析甲状腺功能与胆石症之间的独立关联。
血清TSH水平低（<0.3 mIU/L）的有385人（10.3%），正常的有3321人（88.6%），高（>3 mIU/L）的有43人（1.2%）。男性和女性胆石症的比例分别为14.4%和25.3%。在男性中，血清TSH水平高与胆石症之间存在独立关联（比值比[OR] 3.77；95%置信区间[CI] 1.06 - 13.41；P<0.05）。同样在男性中，血清TSH水平低的人患胆石症的风险有升高趋势（OR 1.40；95% CI 0.96 - 2.02；P = 0.07）。在女性人群中，未发现此类关联。
甲状腺与胆石症之间存在关联，甲状腺功能减退与胆石症之间存在性别特异性关系。
