Department of General Medicine, Ningbo Medical Center Lihuili Hospital, Ningbo, 315000, China.
Health Examination Center, Ningbo Medical Center Lihuili Hospital, Ningbo, 315000, China.
Sci Rep. 2023 Jan 19;13(1):1081. doi: 10.1038/s41598-023-28088-z.
In euthyroid population, it is uncertain whether there is sex-specific difference in the associations of metabolic syndrome (MetS) or its components with gallstone disease (GSD); in general population, MetS increases the risk of GSD. This was a cross-sectional study to investigate the sex-specific difference in the prevalence of MetS according to GSD status and the associations of MetS or its components with GSD in Chinese euthyroid population. The total prevalence of GSD was 8.1% (6.5% in men and 11.0% in women, with a significant difference (p < 0.001)). The total presence of MetS was 10.7% (12.1% in men and 8.2% in women,with a significant difference (p = 0.001)). The age-adjusted odds ratio of MetS for GSD was 2.775 in men (p < 0.001), 2.543 in women (p = 0.007) and 2.503 in the oveall samples (p < 0.001). Univariate analysis revealed that fasting plasma glucose (FPG), high-density lipoprotein cholesterol (HDL-C) and thyroid-stimulating hormone (TSH) were associated with the prevalence of GSD. After adjustment for age, multivariate logistic regression analysis demonstrated that above three parameters were still significantly associated with the risk of GSD in general population; FPG and HDL-C but not TSH levels were significantly associated with the risk of GSD in men; and FPG and TSH levels but not HDL-C in women. Our study demonstrated that in euthyroid population, MetS appeared to be strongly associated with GSD regardless of sex, and FPG and TSH were two independent risk factors for GSD in men, while FPG and HDL-C in women.
在甲状腺功能正常的人群中，代谢综合征（MetS）及其各组分与胆囊疾病（GSD）之间的关联是否存在性别特异性差异尚不确定；一般人群中，MetS 会增加 GSD 的风险。本研究旨在调查中国甲状腺功能正常人群中，根据 GSD 状态，MetS 流行率的性别特异性差异，以及 MetS 或其各组分与 GSD 的相关性。GSD 的总患病率为 8.1%（男性为 6.5%，女性为 11.0%，差异有统计学意义（p<0.001））。MetS 的总检出率为 10.7%（男性为 12.1%，女性为 8.2%，差异有统计学意义（p=0.001））。男性 GSD 患者的 MetS 比值比（OR）为 2.775（p<0.001），女性为 2.543（p=0.007），总样本为 2.503（p<0.001）。单因素分析显示，空腹血糖（FPG）、高密度脂蛋白胆固醇（HDL-C）和促甲状腺激素（TSH）与 GSD 的患病率相关。在校正年龄后，多因素 logistic 回归分析表明，上述三个参数在一般人群中与 GSD 的风险仍显著相关；FPG 和 HDL-C 但不是 TSH 水平与男性 GSD 的风险显著相关；而 FPG 和 TSH 水平但不是 HDL-C 与女性 GSD 的风险显著相关。本研究表明，在甲状腺功能正常的人群中，MetS 似乎与 GSD 密切相关，而与性别无关，FPG 和 TSH 是男性 GSD 的两个独立危险因素，而 FPG 和 HDL-C 是女性 GSD 的两个独立危险因素。
