Morales-Molina José Antonio, Mateu-de Antonio Javier, Marín-Casino Mónica, Grau Santiago
Pharmacy Department, Hospital del Mar, Passeig Marítim, 25-29, 08003 Barcelona, Spain.
J Antimicrob Chemother. 2005 Dec;56(6):1176-8. doi: 10.1093/jac/dki368. Epub 2005 Oct 13.
To study the characteristics of the linezolid-associated serotonin syndrome cases.
Database search for linezolid-associated serotonin syndrome.
Twelve cases were found. The mean age of patients was 52.8 years. All patients received linezolid concomitantly with selective serotonin re-uptake inhibitor drugs (SSRID). The onset of syndrome was 9.5 days after linezolid introduction and was directly correlated to patients' age (P = 0.024). The symptoms resolved in 2.9 days. Citalopram was associated with a delayed resolution (P = 0.018). A trend was observed towards longer resolution time the longer the half-life of the interacting drug (P = 0.096).
Patients are at risk when receiving SSRID concomitant with linezolid. The syndrome onset could be delayed in older patients. The resolution could be delayed when citalopram is involved in the syndrome.
研究与利奈唑胺相关的血清素综合征病例的特征。
通过数据库搜索与利奈唑胺相关的血清素综合征。
共发现12例病例。患者的平均年龄为52.8岁。所有患者均同时接受利奈唑胺和选择性血清素再摄取抑制剂药物（SSRID）。综合征在引入利奈唑胺后9.5天出现，且与患者年龄直接相关（P = 0.024）。症状在2.9天内缓解。西酞普兰与缓解延迟相关（P = 0.018）。观察到相互作用药物的半衰期越长，缓解时间越长的趋势（P = 0.096）。
患者在同时接受SSRID和利奈唑胺时存在风险。老年患者综合征的发作可能会延迟。当西酞普兰参与该综合征时，缓解可能会延迟。
